2-Chlorobenzylideneacetone → HCID 12391100, compound

HRID 1729695Notes

Reaction equation

HRID 1729695 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6](=O)[CH3:7].[CH:13]([O:16][C:17](=[O:22])[CH2:18][C:19](=[NH:21])[NH2:20])([CH3:15])[CH3:14]>C(O)(C)C>[CH:13]([O:16][C:17]([C:18]1[CH:4]([C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=2[Cl:1])[CH:5]=[C:6]([CH3:7])[NH:21][C:19]=1[NH2:20])=[O:22])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 1407602-ChlorobenzylideneacetoneHCID 12391080Amidinoacetic acid isopropyl ester

Product 1

HCID 12391100HCID 12391100, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

Upon heating a solution of 18.1 g of 2-chlorobenzylideneacetone and 14.1 g of amidinoacetic acid isopropyl ester in 200 ml of isopropanol for 3 hours, 2-amino-6-methyl4-(2-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid isopropyl ester of melting point 161°C (isopropanol) is obtained. Yield: 51 percent of theory.

Sources & evidence

ORD record
ord-696819ac1f9d4accb2523ef957f4728e
Source dataset
uspto-grants-1976_11
Patent number
US03989708

Reaction notes

Loading…