Hydrochloric Acid → HCID 21501419, compound

HRID 1729834Notes

Reaction equation

HRID 1729834 reaction equation
Cl.[Cl:2][C:3]1[CH:12]=[C:11]([F:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[NH2:14].C1OC(=O)C2=CC=CC3=C2C1=CC=C3.Cl>CCO>[F:13][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH2:14])=[C:3]([Cl:2])[CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 223824peri-NaphthalideHCID 86734124HCID 86734124, compound

Product 1

HCID 21501419HCID 21501419, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Chloro-4-fluoro-1-naphthylamine hydrochloride-- A mixture of the above naphthalide (10 g), concd. hydrochloric acid (100 ml), and EtOH (100 ml) was refluxed for 8 hrs. The seperated material was filtered from the cold mixture, washed with water, and dried. Crystallization from EtOH gave colorless needles (16.2 g) of mp 215°-217° C.

Workup

  1. filtrationThe seperated material was filtered from the cold mixture
  2. washwashed with water
  3. customdried
  4. customCrystallization from EtOH

Sources & evidence

ORD record
ord-289202e1682c40869199e9ee8f8bb3b1
Source dataset
uspto-grants-1976_11
Patent number
US03989746

Reaction notes

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