反应详情

A solution of fluorene-2-acetonitrile (2g.) in dimethylformamide is treated with sodium hydride (415mg.) portionwise while stirring under nitrogen. After the evolution of hydrogen has ceased, the mixture is cooled to 10°-15° and treated dropwise with methyl iodide (2.82g.) in dimethylformamide (10ml.). After stirring for 30 minutes, the ice bath is removed and the mixture stirred at room temperature overnight. The reaction mixture is then poured into ice water and extracted with ether. The ether extracts are washed with water, dried (MgSO4) and evaporated to give the title compound.

1. temperaturethe mixture is cooled to 10°-15°
2. stirringAfter stirring for 30 minutes
3. customthe ice bath is removed
4. stirringthe mixture stirred at room temperature overnight
5. additionThe reaction mixture is then poured into ice water
6. extractionextracted with ether
7. washThe ether extracts are washed with water
8. dry with materialdried (MgSO4)
9. customevaporated