3,4,5,6-Tetrahydrophthalic anhydride → HCID 20541555, compound

HRID 1729936Notes

Reaction equation

HRID 1729936 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[C:10]1(=[O:20])[O:15][C:13](=[O:14])[C:12]2[CH2:16][CH2:17][CH2:18][CH2:19][C:11]1=2>C(OCC)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]([C:11]2[CH2:19][CH2:18][CH2:17][CH2:16][C:12]=2[C:13]([OH:15])=[O:14])=[O:20])=[C:4]([F:9])[CH:3]=1

Participants

4

Reactant 2

HCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 938984-Chloro-2-fluoroaniline

Product 1

HCID 20541555HCID 20541555, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4.8 Parts of 4-chloro-2-fluoroaniline were added to a solution of 5 parts of 3,4,5,6-tetrahydrophthalic anhydride in 150 parts of diethyl ether and stirred for 1.5 hours. The solution was evaporated under reduced pressure of 300 mm. Hg at 25° C to isolate 9 parts of 2-(4-chloro-2-fluorophenylaminocarbonyl)-cyclohexene-1-carboxylic acid as white crystals melting at 91°-93° C.

Workup

  1. customThe solution was evaporated under reduced pressure of 300 mm. Hg at 25° C

Sources & evidence

ORD record
ord-ddfcdd4f88f84c2b98db1307f5a0f62a
Source dataset
uspto-grants-1976_11
Patent number
US03990880

Reaction notes

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