反应详情

To a stirred solution of 14.1 parts of methyl 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoate and 6.8 parts of lithium iodide in 120 parts of acetonitrile are added portionwise, during a 5-minutes-period, 2 parts of sodium borohydride. Upon completion, stirring is continued overnight at reflux temperature. The reaction mixture is allowed to cool to room temperature. Then there are added successively 100 parts of a concentrated hydrochloric acid solution (carefully) and after stirring for 30 minutes, 1000 parts of water. The product is extracted twice with 2,2'-oxybispropane. The combined extracts are washed twice with water, dried, filtered and evaporated, yielding 11.2 parts of 2,4-dichloro-β-(2,6-dichlorophenyl)benzenepropanol.

1. temperatureat reflux temperature
2. stirringafter stirring for 30 minutes
3. extractionThe product is extracted twice with 2,2'-oxybispropane
4. washThe combined extracts are washed twice with water
5. customdried
6. filtrationfiltered
7. customevaporated