Piperazine → 2-[2-(1-Piperazinyl)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 1730194Notes

Reaction equation

HRID 1730194 reaction equation
[N:1]1([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:6][CH2:5]C[CH2:3][CH2:2]1.[NH:21]1CCNCC1.N1CCCCC1>>[N:1]1([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:6][CH2:5][NH:21][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 8082PiperidineHCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Product 1

HCID 213908302-[2-(1-Piperazinyl)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

Procedure

The preparation of the subject compound is carried out essentially as described for the 2-piperidino derivative (Example 28), two equivalents of piperazine replacing the piperidine. The crude product is recrystallized from 2-methoxyethanol to yield the pure compound melting at 240°-241° C.

Workup

  1. customThe preparation of the subject compound
  2. customThe crude product is recrystallized from 2-methoxyethanol

Sources & evidence

ORD record
ord-c21a592d9c454a52af4e05a01e218de5
Source dataset
uspto-grants-1976_11
Patent number
US03991200

Reaction notes

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