Potassium Carbonate → HCID 21430607, compound

HRID 1730333Notes

Reaction equation

HRID 1730333 reaction equation
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]=1.[C:13]([NH:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH2:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][N:25]2[CH2:26][CH2:27][CH:22]([NH:21][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:23][CH2:24]2)=[CH:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 121780961-bromo-2-(3-indenyl)ethane

Product 1

HCID 21430607HCID 21430607, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-(2-Bromoethyl)indene (1.12 g.), 4-benzamidopiperidine (1.02 g.) and potassium carbonate (1.38 g.) were heated under reflux in isopropanol (25 ml.) for 24 hours. The mixture was filtered and the filtrate was evaporated. Trituration of the residue with ether gave a solid which was recrystallised twice from aqueous ethanol to provide the title compound, m.p. 148°-149° C. (Found: C, 79.7; H, 7.6; N, 8.0. C23H26N2O requires C, 79.7; H, 7.6; N, 8.1%).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customTrituration of the residue with ether gave a solid which
  4. customwas recrystallised twice from aqueous ethanol

Sources & evidence

ORD record
ord-b63d9eb282644f0184e64824a36879b4
Source dataset
uspto-grants-1976_11
Patent number
US03992389

Reaction notes

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