反应详情

p-Nitrophenylethyl bromide (1.15 g.) was refluxed for 20 hours in isopropylalcohol (75 ml.) with 4-benzamidopiperidine (1.032 g.) and anhydrous potassium carbonate (1.037 g.). The mixture was filtered hot, refrigeratedand product was filtered off (547 mg.), washed with cold isopropyl alcohol and ether. The filtrate was evaporated to yield more product (1.4 g.). Recrystallisation from a mixture of benzene and petroleum ether (b.p. 40°-60° C) gave the title compound, m.p. 209°-216° C. (Found: C, 68.2; H, 6.7; N, 11.8. C20H23N3O3 requires C, 68.0; H, 6.6; N, 11.9%).

1. filtrationThe mixture was filtered hot
2. filtrationrefrigeratedand product was filtered off (547 mg.)
3. washwashed with cold isopropyl alcohol and ether
4. customThe filtrate was evaporated
5. customto yield more product (1.4 g.)
6. customRecrystallisation
7. additionfrom a mixture of benzene and petroleum ether (b.p. 40°-60° C)