Hydrazine hydrate (1:1) → HCID 21497495, compound

HRID 1730400Notes

Reaction equation

HRID 1730400 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[C:13]([CH3:15])[N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:6]=2[CH:35]=1.O.NN>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:16][NH2:17])=[C:13]([CH3:15])[N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:6]=2[CH:35]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21497533HCID 21497533, compound

Product 1

HCID 21497495HCID 21497495, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 28, a suspension of 1.00 mmole of 8-chloro-1-(phthalimido)methyl-2-methyl-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine is treated with 5.00 mmole of hydrazine hydrate in 12ml. of absolute ethanol at room temperature for 18 hours to afford, after removal of the phthalazine by-product, 8-chloro-1-aminomethyl-2-methyl-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine.

Workup

  1. customafter removal of the phthalazine by-product, 8-chloro-1-aminomethyl-2-methyl-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-8a4df32e769d4becb5205fb8327ad7ec
Source dataset
uspto-grants-1976_11
Patent number
US03992408

Reaction notes

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