Chloride → Tert-butyl 2-(6-chloro-5-(trifluoromethyl)pyridin-3-yl)acetate

HRID 173042Notes

Reaction equation

HRID 173042 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:9]([F:10])([F:11])[F:12])[c:5]([Cl:8])[n:6][cH:7]1.[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19]([CH2:20][Zn+:21])=[O:22].[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[Cl-:13]>>[c:2]1([CH2:20][C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:22])[cH:3][c:4]([C:9]([F:10])([F:11])[F:12])[c:5]([Cl:8])[n:6][cH:7]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 218363025-Bromo-2-chloro-3-(trifluoromethyl)pyridineHCID 178451180HCID 178451180, compound

Product 1

HCID 86657956Tert-butyl 2-(6-chloro-5-(trifluoromethyl)pyridin-3-yl)acetate

Sources & evidence

ORD record
ord-b38e1ff0d4254a6a84152137b5c2aacd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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