反应详情

温度

80 °C

A mixture of 166 g of 2,5-dimethoxybenzaldehyde, 76 g of cyanoacetic acid, 5 ml of piperidine and 400 ml of pyridine was heated at 80° C understirring for 2 hours and then refluxed with heating at 140° C for 5 hours. After the reaction, the mixture was cooled to room temperature and poured into 2 liters of ice water. The precipitated crystals were filteredout and recrystallized from ethanol to give 117 g of the end product havinga melting point of 70 ~ 71° C (yield 62%).

1. temperaturerefluxed
2. temperaturewith heating at 140° C for 5 hours
3. customAfter the reaction
4. temperaturethe mixture was cooled to room temperature
5. customrecrystallized from ethanol