3-Nitrobenzaldehyde → HCID 12308269, compound

HRID 1730518Notes

Reaction equation

HRID 1730518 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:22])[CH:16]=[C:17]([NH2:21])[O:18][CH2:19][CH3:20])[CH3:13]>C(O)(C)C>[CH2:12]([O:14][C:15]([C:16]1[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH:16]([C:15]([O:14][CH2:12][CH3:13])=[O:22])[C:17]([O:18][CH2:19][CH3:20])=[N:21][C:17]=1[NH2:21])=[O:22])[CH3:13]

Participants

4

Reactant 2

HCID 74493-NitrobenzaldehydeHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl ester

Product 1

HCID 12308269HCID 12308269, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

Upon heating a solution of 7.6 g of 3-nitrobenzaldehyde and 15.9 g of 3-amino-3-ethoxyacrylic acid ethyl ester in 50 ml of isopropanol for 6 hours, 2-amino-4-(3-nitrophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 129° (isopropanol) is obtained.

Sources & evidence

ORD record
ord-bdeca15ca1f84dcf8ab43e2112fbe275
Source dataset
uspto-grants-1976_11
Patent number
US03992545

Reaction notes

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