Malonic Acid → HCID 20535692, compound

HRID 1730691Notes

Reaction equation

HRID 1730691 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1C=O.[C:8](O)(=O)[CH2:9][C:10]([OH:12])=[O:11].N1CCCCC1>N1C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:9](=[CH2:8])[C:10]([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 867Malonic Acid2×HCID 73642-Thiophenecarboxaldehyde2×HCID 8082Piperidine

Product 1

HCID 20535692HCID 20535692, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-thienyl acrylic acid was prepared by reaction of 2-thiophene carboxaldehyde with malonic acid. A solution of 2-thiophene carboxaldehyde (25.7 g.), malonic acid (41.6 g.), pyridine (100 ml.), and piperidine (2 ml.) was refluxed for 31/2 hours. 2-thienyl acrylic acid was recovered from the reaction mixture in a manner parallel to that described in Example 41.

Workup

  1. custom2-thienyl acrylic acid was recovered from the reaction mixture in a manner parallel to

Sources & evidence

ORD record
ord-c12c374d007e410e810daad40783549c
Source dataset
uspto-grants-1976_11
Patent number
US03993684

Reaction notes

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