Water → HCID 53655940, compound

HRID 1730755Notes

Reaction equation

HRID 1730755 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:18]([CH3:20])=[O:19])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1.[C:21](=O)([O-])[O-].[K+].[K+].CI.O>CS(C)=O>[CH3:21][O:16][C:15](=[O:17])[CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:9][CH:10]=1)[S:18]([CH3:20])=[O:19]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 53655673HCID 53655673, compound

Product 1

HCID 53655940HCID 53655940, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of 11.5 gm (39.3 millimols) of (2'-fluoro-4-biphenylyl)-methyl-sulfinyl-acetic acid in 60 ml of dimethyl sulfoxide, was admixed with 8.2 gm of dry potassium carbonate and 8.4 gm of methyl iodide, and the mixture was stirred at room temperature for 3 hours. Thereafter, water was added, whereupon the reaction product crystallized out and was suction-filtered off, dried and recrystallized from carbon tetrachloride and isopropanol Yield: 3.8 gm (32% of theory); m.p. 79°-80° C

Workup

  1. customcrystallized out and
  2. filtrationwas suction-filtered off
  3. customdried
  4. customrecrystallized from carbon tetrachloride and isopropanol Yield: 3.8 gm (32% of theory)

Sources & evidence

ORD record
ord-0752383eec174b48b0ff676255aab6eb
Source dataset
uspto-grants-1976_11
Patent number
US03993683

Reaction notes

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