Triethyl orthoacetate → 7-Chloro-5-(2-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-A]quinoline

HRID 1730764Notes

Reaction equation

HRID 1730764 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][NH2:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20].[C:21](OCC)(OCC)(OCC)[CH3:22]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:21]([CH3:22])=[N:13][N:12]=[C:7]1[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20]

Participants

4

Reactant 2

HCID 66221Triethyl orthoacetateHCID 214886206-Chloro-4-(2-chlorophenyl)-2-hydrazinylquinoline

Product 1

HCID 214885877-Chloro-5-(2-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-A]quinoline

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Preparation 5, 6-chloro-2-hydrazino-4-(o-chlorophenyl)quinoline and triethyl orthoacetate in xylene were refluxed to give 7-chloro-1-methyl-5-(o-chlorophenyl)-s-triazolo[4,3-a]quinoline.

Workup

  1. temperaturewere refluxed

Sources & evidence

ORD record
ord-a106a269e2cd413ab5b6753e51f53205
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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