Hydrazine hydrate (1:1) → Clonazolam

HRID 1730768Notes

Reaction equation

HRID 1730768 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:19]2[C:23]([CH3:24])=[N:22][N:21]=[C:20]2[CH2:25][N:26]2C(=O)C3=CC=CC=C3C2=O)=[C:8]([CH:18]=1)[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17])=O)([O-:3])=[O:2].O.NN>C(O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:19]3[C:23]([CH3:24])=[N:22][N:21]=[C:20]3[CH2:25][N:26]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[Cl:17])[C:8]=2[CH:18]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21496157HCID 21496157, compound

Product 1

HCID 12317881Clonazolam

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 4, 5-nitro-2'-chloro-2-[3-(phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone was heated in ethanol with hydrazine hydrate to give 8-nitro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-bfae0bc6f141443cb5853cbd487ee73a
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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