Hydrazine hydrate (1:1) → HCID 21496163, compound

HRID 1730773Notes

Reaction equation

HRID 1730773 reaction equation
[CH:1]([S:4]([C:7]1[CH:8]=[CH:9][C:10]([N:22]2[C:26]([CH2:27][CH2:28][CH3:29])=[N:25][N:24]=[C:23]2[CH2:30][N:31]2C(=O)C3=CC=CC=C3C2=O)=[C:11]([CH:21]=1)[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])=O)(=[O:6])=[O:5])([CH3:3])[CH3:2].O.NN>CO>[CH2:27]([C:26]1[N:22]2[C:10]3[CH:9]=[CH:8][C:7]([S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[CH:21][C:11]=3[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])=[N:31][CH2:30][C:23]2=[N:24][N:25]=1)[CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21496135HCID 21496135, compound

Product 1

HCID 21496163HCID 21496163, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 5, a solution of 5-isopropylsulfonyl-2'-fluoro-2-[3-(phthalimidomethyl)-5-propyl-4H-1,2,4-triazol-4-yl]benzophenone in methanol was heated with hydrazine hydrate to give 1-propyl-8-isopropylsulfonyl-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-03b8e49669934aaeb80386aa95b3046f
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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