反应详情

A solution of triphenylphosphine (4.98 g, 2 equiv.) in ethyl acetate (30 ml) was added over a period of 15 minutes to a stirred solution of 2,2,2-trichloroethyl 3-bromomethyl-7β-phenylacetamidoceph-3-em-4-carboxylate (5.2 g, ca. 9.5 mmole) in ethyl acetate. The mixture was stirred in the absence of light for 2 hours when the precipitated solid was filtered off, washed with ethyl acetate and dried to give the title phosphonium salt (6.17 g, 81%), λmax. (EtOH) 268.5 nm (ε 10,450) and 275.5 nm (ε 10,050), νmax. (CHBr3) 3412 (NH), 1784 (azetidin-2-one), 1722 (CO2R), 1678 and 1498 (CONH) and 1440 cm-1 (P-+C6H5).

1. filtrationwas filtered off
2. washwashed with ethyl acetate
3. customdried