Sodium Bicarbonate → HCID 67894209, compound

HRID 1730902Notes

Reaction equation

HRID 1730902 reaction equation
C(C1C=CC=CC=1C([NH:8][CH:9]1[C:24](=[O:25])[N:11]2[C:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[C:13]([CH3:16])[CH2:14][S:15][C@H:10]12)=O)(O)=O.Cl.NC1C(=O)N2C(C(OC(C)(C)C)=O)=C(C)CS[C@H]12.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH2:8][CH:9]1[C:24](=[O:25])[N:11]2[C:12]([C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])=[C:13]([CH3:16])[CH2:14][S:15][C@H:10]12

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 70476002HCID 70476002, compoundHCID 70632761HCID 70632761, compound

Product 1

HCID 67894209HCID 67894209, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In accordance with the procedure of Example 2, t-butyl 7-(2-carboxybenzamido)-3-methyl-3-cephem-4-carboxylate is converted to t-butyl 7-amino-3-methyl-3-cephem-4-carboxylate hydrochloride. The hydrochloride salt is converted to the free amino este, a colorless solid, using ethyl acetate and sodium bicarbonate.

Sources & evidence

ORD record
ord-e51a4ee8e4ea4fceb56586f8f57cd40c
Source dataset
uspto-grants-1976_11
Patent number
US03994888

Reaction notes

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