Hydrochloric Acid → HCID 131710539, compound

HRID 1730912Notes

Reaction equation

HRID 1730912 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][CH2:5][S:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[NH:15][C:14](=[O:17])[CH2:13][CH:12]2[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[ClH:25]>C(Cl)(Cl)Cl.CCOCC>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][S:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[NH:15][C:14](=[O:17])[CH2:13][CH:12]2[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21494334HCID 21494334, compound

Product 1

HCID 131710539HCID 131710539, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

A solution of 8-[[3-(dimethylamino)propyl]thio]-3,4-dihydro-4-phenyl-2(1H)-quinolinone (5.0g) in 50 ml of chloroform is treated with 2.1 ml of 6.9N ethanolic hydrogen chloride and the resulting solution is slowly diluted to 200 ml with ether to yield 5.5g of a colorless solid, melting point 179°-181° C. After crystallization from 70 ml of acetonitrile, the product weighs 5.0g, melting point 181°-183° C.

Sources & evidence

ORD record
ord-503fb8e3c35a4f9a9ea441da3aa10022
Source dataset
uspto-grants-1976_11
Patent number
US03994900

Reaction notes

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