Isopropyl chloroformate → HCID 21494443, compound

HRID 1730956Notes

Reaction equation

HRID 1730956 reaction equation
[CH2:1]([C:8]1[N:12]=[C:11]([OH:13])[O:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22]>>[CH2:1]([C:8]1[N:12]([C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22])[C:11](=[O:13])[O:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 7917Isopropyl chloroformateHCID 11430Potassium CarbonateHCID 178517637HCID 178517637, compound

Product 1

HCID 21494443HCID 21494443, compound

Procedure

17.6 parts of 3-benzyl-5-hydroxy-1,2,4-oxadiazole, 6.9 parts of potassium carbonate and 12.3 parts of isopropyl chloroformate are heated for 5 hours at 60° C. After the mixture has cooled, the precipitated potassium chloride is removed by suction filtration and the filtrate concentrated. The residue is recrystallized from n-propanol. There is obtained 15.5 parts (59% of theory) of the desired product; m.p.: 80° C.

Workup

  1. temperatureAfter the mixture has cooled
  2. customthe precipitated potassium chloride is removed by suction filtration
  3. concentrationthe filtrate concentrated
  4. customThe residue is recrystallized from n-propanol

Sources & evidence

ORD record
ord-e60a077343b849f2ba54514053e1ba49
Source dataset
uspto-grants-1976_11
Patent number
US03994909

Reaction notes

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