Formaldehyde → HCID 21494813, compound

HRID 1731077Notes

Reaction equation

HRID 1731077 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH3:17])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:8]=2[CH:25]=1)([O-:3])=[O:2].[CH2:26]=[O:27]>C1(C)C(C)=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][CH2:26][OH:27])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:8]=2[CH:25]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 12317881Clonazolam

Product 1

HCID 21494813HCID 21494813, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 1, 8-nitro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine in xylene was heated in an oil bath with repeated additions of portions of paraformaldehyde to give 8-nitro-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-7d011f72d7ba4b2b99aefb332324281d
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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