Phthalimide → HCID 21494828, compound

HRID 1731078Notes

Reaction equation

HRID 1731078 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][CH2:18]O)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[C:8]=2[CH:27]=1)([O-:3])=[O:2].[C:28]1(=[O:38])[NH:32][C:31](=[O:33])[C:30]2=[CH:34][CH:35]=[CH:36][CH:37]=[C:29]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCOCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][CH2:18][N:32]4[C:28](=[O:38])[C:29]5=[CH:37][CH:36]=[CH:35][CH:34]=[C:30]5[C:31]4=[O:33])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[C:8]=2[CH:27]=1)([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21494813HCID 21494813, compound

Product 1

HCID 21494828HCID 21494828, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In the manner given in Example 2, 8-nitro-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine in dioxane is treated with phthalimide, triphenylphosphine and subsequently with diethyl azodicarboxylate to give 8-nitro-1-(2-phthalimidoethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-c1b206c44b8d4032bc7c98404ea6b032
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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