Formaldehyde → HCID 21494826, compound

HRID 1731079Notes

Reaction equation

HRID 1731079 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH3:16])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:7]=2[CH:24]=1.[CH2:27]=[O:28]>C1(C)C(C)=CC=CC=1>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][CH2:27][OH:28])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:7]=2[CH:24]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 21494847HCID 21494847, compound

Product 1

HCID 21494826HCID 21494826, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 1, 8-trifluoromethyl-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine in xylene is heated with excess paraformaldehyde in a sealed, glass-lined vessel at 155°-160° C. to give 8-trifluoromethyl-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-2c734a1e2ba1413ca392fda2ef7568ac
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

Loading…