Phthalimide → HCID 12612398, compound

HRID 1731081Notes

Reaction equation

HRID 1731081 reaction equation
O[CH2:2][CH2:3][C:4]1[N:8]2[C:9]3[CH:24]=[CH:23][CH:22]=[CH:21][C:10]=3[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])=[N:12][CH2:13][C:7]2=[N:6][N:5]=1.[C:25]1(=[O:35])[NH:29][C:28](=[O:30])[C:27]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCOCC1>[C:25]1(=[O:35])[N:29]([CH2:2][CH2:3][C:4]2[N:8]3[C:9]4[CH:24]=[CH:23][CH:22]=[CH:21][C:10]=4[C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[Cl:20])=[N:12][CH2:13][C:7]3=[N:6][N:5]=2)[C:28](=[O:30])[C:27]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]12

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21494817HCID 21494817, compound

Product 1

HCID 12612398HCID 12612398, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In the manner given in Example 2, 1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dioxane is treated with phthalimide, triphenylphosphine and subsequently with diethyl azodicarboxylate to give 1-(2-phthalimidoethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-d9eeea6a6f1d4785ac937a59b847893c
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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