HRID1731104

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6809

Phthalimide

C8H5NO2

HCID11776

Triphenylphosphine

C18H15P

HCID220568

Diethyl azodicarboxylate

C6H10N2O4

结构：CN(C)CCc1nnc(CO)n1-c1ccc(Cl)cc1C(=O)c1ccccc1Cl

HCID21494734

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCc1nnc(CN2C(=O)c3ccccc3C2=O)n1-c1ccc(Cl)cc1C(=O)c1ccccc1Cl

HCID21494795

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

In the manner given in Example 1B, 2',5-dichloro-2-[3-[2-(dimethylamino)ethyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenone in 1,2-dimethoxyethane is treated with phthalimide, triphenylphosphine and diethyl azodicarboxylate to give 2',5-dichloro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4,-triazol-4-yl]benzophenone.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9fe3457ca838464aacef291c03a95929
来源数据集: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03994940
来源说明: uspto-grants-1976_11

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:28])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21]O)=[N:19][N:18]=[C:17]1[CH2:23][CH2:24][N:25]([CH3:27])[CH3:26].[C:29]1(=[O:39])[NH:33][C:32](=[O:34])[C:31]2=[CH:35][CH:36]=[CH:37][CH:38]=[C:30]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>COCCOC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:28])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:33]2[C:29](=[O:39])[C:30]3=[CH:38][CH:37]=[CH:36][CH:35]=[C:31]3[C:32]2=[O:34])=[N:19][N:18]=[C:17]1[CH2:23][CH2:24][N:25]([CH3:26])[CH3:27]