Phthalimide → HCID 21494772, compound

HRID 1731106Notes

Reaction equation

HRID 1731106 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:30])[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]1[C:22]([CH2:23]O)=[N:21][N:20]=[C:19]1[CH2:25][CH2:26][N:27]([CH3:29])[CH3:28].[C:31]1(=[O:41])[NH:35][C:34](=[O:36])[C:33]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:32]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>COCCOC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:30])[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]1[C:22]([CH2:23][N:35]2[C:31](=[O:41])[C:32]3=[CH:40][CH:39]=[CH:38][CH:37]=[C:33]3[C:34]2=[O:36])=[N:21][N:20]=[C:19]1[CH2:25][CH2:26][N:27]([CH3:28])[CH3:29]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21494780HCID 21494780, compound

Product 1

HCID 21494772HCID 21494772, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

In the manner given in Example 1B, 2'-chloro-5-nitro-2-[3-[2-(dimethylamino)ethyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenone in 1,2-dimethoxyethane is treated with phthalimide, triphenylphosphine and diethyl azodicarboxylate to give 2'-chloro-5-nitro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-ebac834914d44f0c9606385d2e235a3e
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

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