Phthalimide → HCID 21494755, compound

HRID 1731108Notes

Reaction equation

HRID 1731108 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21]O)=[N:19][N:18]=[C:17]2[CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[C:28]1(=[O:38])[NH:32][C:31](=[O:33])[C:30]2=[CH:34][CH:35]=[CH:36][CH:37]=[C:29]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>COCCOC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:32]3[C:28](=[O:38])[C:29]4=[CH:37][CH:36]=[CH:35][CH:34]=[C:30]4[C:31]3=[O:33])=[N:19][N:18]=[C:17]2[CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21494784HCID 21494784, compound

Product 1

HCID 21494755HCID 21494755, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

In the manner given in Example 1B, 5-fluoro-2-[3-[2-(dimethylamino)ethyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenone in 1,2-dimethoxyethane is treated with phthalimide, triphenylphosphine and diethyl azodicarboxylate to give 5-fluoro-2-[3-[2-(dimethylamino)-ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-2dfa4878af53476697d4786999777862
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

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