Phthalimide → HCID 21494774, compound

HRID 1731116Notes

Reaction equation

HRID 1731116 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[CH:5][C:6]([N:18]2[C:22]([CH2:23]O)=[N:21][N:20]=[C:19]2[CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])=[C:7]([CH:17]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])=[O:9].[C:32]1(=[O:42])[NH:36][C:35](=[O:37])[C:34]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:33]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>COCCOC>[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[CH:5][C:6]([N:18]2[C:22]([CH2:23][N:36]3[C:32](=[O:42])[C:33]4=[CH:41][CH:40]=[CH:39][CH:38]=[C:34]4[C:35]3=[O:37])=[N:21][N:20]=[C:19]2[CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])=[C:7]([CH:17]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])=[O:9]

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21494767HCID 21494767, compound

Product 1

HCID 21494774HCID 21494774, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

In the manner given in Example 1B, 5-(trifluoromethyl)-2'-chloro-2-[3-[2-(dimethylamino)ethyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenone in 1,2-dimethoxyethane is treated with phthalimide, triphenylphosphine and diethyl azodicarboxylate to give 5-(trifluoromethyl)-2'-chloro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-a769388c501847c098fc45f8eabc5ca6
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

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