Hydrochloric Acid → HCID 131710559, compound

HRID 1731236Notes

Reaction equation

HRID 1731236 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])[CH2:3][S:4][CH2:5][NH:6][C:7]([CH3:9])=[O:8].[ClH:25]>CO.O1CCOCC1>[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])[CH2:3][S:4][CH2:5][NH:6][C:7]([CH3:9])=[O:8].[ClH:25]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131710561HCID 131710561, compound

Product 1

HCID 131710559HCID 131710559, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

5 g of Boc-Cys(Acm)-Gly-OMe are dissolved in 20 ml of methanol and 50 ml of 4.4 N HCl in dioxane are added. After 10 minutes at 25°C, the mixture is concentrated to half its volume and 100 ml of ether are added. The mother liquor is separated from the resulting amorphous precipitate and the latter is dried.

Workup

  1. concentrationthe mixture is concentrated to half its volume and 100 ml of ether
  2. additionare added
  3. customThe mother liquor is separated from the resulting amorphous precipitate
  4. customthe latter is dried

Sources & evidence

ORD record
ord-ad1ca0a550494561bd8e1207294af12b
Source dataset
uspto-grants-1976_11
Patent number
US03994871

Reaction notes

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