Toluene → Ethyl 3-oxo-1-(phenylmethyl)-4-piperidinecarboxylate

HRID 1731286Notes

Reaction equation

HRID 1731286 reaction equation
C(O[C:4](=[O:20])[CH2:5][N:6]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:7][CH2:8][CH2:9][C:10]([O-:12])=[O:11])C.[H-].[Na+].[C:23]1(C)C=CC=C[CH:24]=1>>[O:20]=[C:4]1[CH:9]([C:10]([O:12][CH2:23][CH3:24])=[O:11])[CH2:8][CH2:7][N:6]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:5]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 24758Sodium hydrideHCID 20228749HCID 20228749, compound

Product 1

HCID 419705Ethyl 3-oxo-1-(phenylmethyl)-4-piperidinecarboxylate

Procedure

The anion of ethyl 3-oxo-1-phenylmethyl-4-piperidinecarboxylate is prepared according to Example 1(a) above, from 30.7 g (0.1 mole) of 4-[(2-ethoxy-2-oxoethyl)(phenylmethyl)amino]butanoate in 700 ml of toluene and 5 g (0.1 mole) of 50% strength sodium hydride.

Sources & evidence

ORD record
ord-4c6a48ec9acb4711ac40246b75796c04
Source dataset
uspto-grants-1986_11
Patent number
US04621087

Reaction notes

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