反应详情

A mixture of methyl 2-mercapto-5-trifluoromethylbenzoate (0.94 g, 0.0040 moles), chloromethylphenylsulfoxide (0.70 g, 0.0040 moles) and K2CO3 (1.66 g, 0.012 moles) in DMF (10 ml) was stirred vigorously at 50° for 45 minutes. The reaction was cooled, diluted with water (30 ml), and the resulting precipitate collected, water and hexane washed, and dried under vacuum to afford 1.05 g (70%) of methyl 2-phenylsulfonylmethylthio-5-trifluoromethylbenzoate. Rf (Et2O:Hexane, 1:1+1% Acetic Acid)=0.15.

1. temperatureThe reaction was cooled
2. customthe resulting precipitate collected
3. washwater and hexane washed
4. customdried under vacuum