Hydroxyamine hydrochloride → HCID 13732599, compound

HRID 1731525Notes

Reaction equation

HRID 1731525 reaction equation
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:13](=O)[C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)[C:11]([OH:12])=[C:6]2[CH:5]=[N:4]1)[CH3:2].Cl.[NH2:23]O>N1C=CC=CC=1>[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=4)=[N:23][O:12][C:11]3=[C:6]2[CH:5]=[N:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 178463023HCID 178463023, compound

Product 1

HCID 13732599HCID 13732599, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-Ethyl-4-hydroxy-5-(4-methylbenzoyl)-1H-pyrazolo[3,4-b]pyridine (1.45 g) was refluxed overnight in 20 ml of pyridine containing 3.0 g of hydroxylamine hydrochloride. The pyridine was then evaporated and the residue triturated with 5% hydrochloric acid and then washed with methanol. In this manner 1.26 g of product was obtained, mp 173°-175° C. An analytical sample was recrystallized from dichloromethane/hexane and the melting point was unchanged.

Workup

  1. customThe pyridine was then evaporated
  2. customthe residue triturated with 5% hydrochloric acid
  3. washwashed with methanol

Sources & evidence

ORD record
ord-8ca1379a4f2d4ffca4ea6e0c35ae8461
Source dataset
uspto-grants-1986_11
Patent number
US04622326

Reaction notes

Loading…