反应详情

Dicyclohexylcarbodiimide (2.00 g) in N,N-dimethylformamide (10 ml) was added to a solution of 1-hydroxybenzotriazole (1.37 g), 2-(4-methoxyphenyl)ethanamine (1.51 g) and 3-chloromandelic acid (1.86 g) in N,N-dimethylformamide (40 ml) and the mixture stirred for 18 hours, filtered then evaporated to dryness. The residue was dissolved in dichloromethane, washed with aqueous 4M hydrochloric acid and sodium bicarbonate solution, dried (magnesium sulphate), filtered and evaporated to dryness to give the title compound as an oil which was used without further purification.

1. filtrationfiltered
2. customthen evaporated to dryness
3. dissolutionThe residue was dissolved in dichloromethane
4. washwashed with aqueous 4M hydrochloric acid and sodium bicarbonate solution
5. dry with materialdried (magnesium sulphate)
6. filtrationfiltered
7. customevaporated to dryness