Hydrochloric Acid → HCID 178418600, compound

HRID 1731590Notes

Reaction equation

HRID 1731590 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].Cl.CO.C(O)(C)C>Cl.CC(O)=O>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3776IsopropanolHCID 178454187HCID 178454187, compound

Product 1

HCID 178418600HCID 178418600, compoundYield 163%

Reagents, catalysts & solvents 1

HCID 22641269Acetate-hydrochloric acidSolvent

Procedure

243.7 Grams (0.55 mol) of BOC-Arg-CHA.HCl was dissolved in 1,093 ml of 2N-HCl/AcOH and a small quantity of MeOH, and the mixture was reacted at room temperature for 1 hour. After the reaction was completed, to the reaction mixture was added with 1,093 ml of isopropanol and reprecipitated in AcOEt. The crystals precipitated were collected by filtration and dried to obtain 156.2 g (74.3%) of H-Arg-CHA.2HCl. Rf3 =0.15. Melting point: 240.5° C. (decomposed). [α]D20 +53.5 (C=1, H2O)

Workup

  1. customreprecipitated in AcOEt
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-674040937d0b451a82ae6434785cdf52
Source dataset
uspto-grants-1986_11
Patent number
US04622389

Reaction notes

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