Hydrochloric Acid → HCID 70539942, compound

HRID 1731666Notes

Reaction equation

HRID 1731666 reaction equation
[NH2:1][C:2]1[CH2:6][CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]([C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[N:3]=1.[ClH:22]>CN(C)C=O>[ClH:22].[NH2:1][C:2]1[CH2:6][CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]([C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20228192HCID 20228192, compound

Product 1

HCID 70539942HCID 70539942, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 2.0 g. amount of 2-(3-amino-5-phenyl-2-pyrazolin-1-yl)benzothiazole (Example 6) is dissolved in 20.0 ml. of N,N-dimethylformamide. The solution is acidified with 5N ethanolic hydrochloric acid. The solvent is removed in vacuo and the residue is crystallized from ether-methanol at 5° C. to give 2.0 g. of the product of the Example as green crystals, m.p. 275°-285° C.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is crystallized from ether-methanol at 5° C.
  3. customto give 2.0 g

Sources & evidence

ORD record
ord-3017def4f77548ad8f323e0e9fcc3035
Source dataset
uspto-grants-1986_11
Patent number
US04622401

Reaction notes

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