反应详情

温度

100 °C

55.2 g of sodium was added portionwise to 1500 ml of anhydrous methanol. When the reaction was complete 120 g of phenol and 200 g of 2-chloronicotinic acid were added, and the mixture was heated until completely solubilized. The methanol was removed by distillation, and the residue heated to 180°-200° C. for 5 minutes. The molten mass was cooled to about 100° C., and water was added slowly. The solution obtained was acidified with hydrochloric acid. After standing for about 16 hours, the solid obtained was filtered and dried, giving 237.4 g of 2-phenoxynicotinic acid, as white crystals, m.p. 179-181° C. (Kofler micro hot-stage); neutralization equivalent: 215.20 (calculated 216.55).

1. additionwere added
2. temperaturethe mixture was heated
3. customThe methanol was removed by distillation
4. temperaturethe residue heated to 180°-200° C. for 5 minutes
5. additionwater was added slowly
6. customThe solution obtained
7. customthe solid obtained
8. filtrationwas filtered
9. customdried