Acetate → N-[6-(2-phenylethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

HRID 173191Notes

Reaction equation

HRID 173191 reaction equation
[C:80]([O-:81])(=[O:82])[CH3:83].[C:85]([O-:86])(=[O:87])[CH3:88].[CH2:10]=[CH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:89][CH2:90][O:91][C:92](=[O:93])[CH3:94].[CH:1]12[CH2:2][CH2:3][CH2:4][CH:5]([BH:6]1)[CH2:7][CH2:8][CH2:9]2.[CH:46]1([P:47]([CH:48]2[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][c:59]2-[c:60]2[cH:61][cH:62][cH:63][cH:64][c:65]2[N:66]([CH3:67])[CH3:68])[CH2:69][CH2:70][CH2:71][CH2:72][CH2:73]1.[Cl:20][c:21]1[cH:22][cH:23][c:24]2[c:25]([NH:38][C:39]([CH2:40][CH2:41][CH3:42])=[O:43])[n:26][n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[c:28]2[cH:29]1.[Cs+:45].[F-:44].[Na+:19].[O:74]1[CH2:75][CH2:76][O:77][CH2:78][CH2:79]1.[OH-:18].[OH2:95].[Pd+2:84]>>[CH2:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:21]1[cH:22][cH:23][c:24]2[c:25]([NH:38][C:39]([CH2:40][CH2:41][CH3:42])=[O:43])[n:26][n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[c:28]2[cH:29]1

Participants

14

Reactant 13

HCID 175Acetate2×HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 7501StyreneHCID 8857Ethyl AcetateHCID 28179Fluoride IonHCID 312751,4-DioxaneHCID 789669-Borabicyclo(3.3.1)nonaneHCID 104967Cesium cationHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342172-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenylHCID 10406687N-[6-chloro-1-[[2-(trimethylsilyl)ethoxy)methyl]-1H-indazol-3-yl)butanamide

Product 1

HCID 22319517N-[6-(2-phenylethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

Sources & evidence

ORD record
ord-2c2a87ab47554bcfbced85e81f62ab6a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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