Methylamine → HCID 12491965, compound

HRID 1732022Notes

Reaction equation

HRID 1732022 reaction equation
[CH2:1]=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:16][NH2:17]>C(O)C>[CH3:16][NH:17][CH2:1][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 11117162Ethyl alpha-(phenethyl)acrylate

Product 1

HCID 12491965HCID 12491965, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

26.3 g of ethyl 2-methylene-4-phenylbutyrate (1.4) and 4 g of methylamine in 150 ml of ethanol in an autoclave were heated at 80° C. for 10 hours. After cooling down, the ethanol was removed, the residue was taken up in 1N HCl, this was extracted with ether, made alkaline with sodium carbonate and again extracted, dried and evaporated.

Workup

  1. temperatureAfter cooling down
  2. customthe ethanol was removed
  3. extractionthis was extracted with ether
  4. extractionagain extracted
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-841653cccc004927be79159700e4b5a3
Source dataset
uspto-grants-1986_11
Patent number
US04624962

Reaction notes

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