Ethyl chloroformate → 4-Amino-5-chloro-N-(1,2-dimethyl-4-pyrazolidinyl)-2-methoxybenzamide

HRID 1732031Notes

Reaction equation

HRID 1732031 reaction equation
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([O:12][CH3:13])[CH:3]=1.C(OC(Cl)=O)C.[NH2:20][CH:21]1[CH2:25][N:24]([CH3:26])[N:23]([CH3:27])[CH2:22]1>C(N(CC)CC)C>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:5]([C:6]([NH:20][CH:21]2[CH2:25][N:24]([CH3:26])[N:23]([CH3:27])[CH2:22]2)=[O:8])=[C:4]([O:12][CH3:13])[CH:3]=1

Participants

5

Reactant 3

HCID 10928Ethyl chloroformateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 20226460HCID 20226460, compound

Product 1

HCID 137468954-Amino-5-chloro-N-(1,2-dimethyl-4-pyrazolidinyl)-2-methoxybenzamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared as described in Example 8 of U.S. Pat. No. 4,207,327 from 4-amino-5-chloro-2-methoxybenzoic acid, triethylamine, ethylchlorocarbonate and 4-amino-1,2-dimethylpyrazolidine, m.p. 169°-171° C.

Sources & evidence

ORD record
ord-687453c25c60477f97f710c5822f4ba6
Source dataset
uspto-grants-1986_11
Patent number
US04624961

Reaction notes

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