Succinic Acid → 106613-26-7

HRID 1732042Notes

Reaction equation

HRID 1732042 reaction equation
[NH2:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]([C:6]([NH:8][CH:9]2[CH2:13][N:12]([CH2:14][CH3:15])[N:11]([CH2:16][CH3:17])[CH2:10]2)=[O:7])=[C:4]([O:21][CH3:22])[CH:3]=1.[C:23]([OH:30])(=[O:29])[CH2:24][CH2:25][C:26]([OH:28])=[O:27].C(OC(C)C)(C)C>C(O)(C)C>[C:23]([OH:30])(=[O:29])[CH2:24][CH2:25][C:26]([OH:28])=[O:27].[NH2:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]([C:6]([NH:8][CH:9]2[CH2:13][N:12]([CH2:14][CH3:15])[N:11]([CH2:16][CH3:17])[CH2:10]2)=[O:7])=[C:4]([O:21][CH3:22])[CH:3]=1

Participants

5

Reactant 3

HCID 1110Succinic AcidHCID 7914Diisopropyl EtherHCID 548014-Amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy-benzamide

Product 1

HCID 6917727106613-26-7

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Amino-5-chloro-2-methoxy-N-(1,2-diethyl-4-pyrazolidinyl)benzamide as prepared in Example 6 of U.S. Pat. No. 4,207,327 was added to an isopropyl alcohol solution containing a molecularly equivalent amount of succinic acid. Isopropyl ether was added to precipitate the succinate salt which was then recrystallized from isopropyl ether-isopropyl alcohol mixture. The salt was vacuum dried at 60° C., m.p. 99°-101° C.

Workup

  1. customto precipitate the succinate salt which
  2. customwas then recrystallized from isopropyl ether-isopropyl alcohol mixture
  3. customdried at 60° C.

Sources & evidence

ORD record
ord-c9647e1faa364805986a30cd9ef5b062
Source dataset
uspto-grants-1986_11
Patent number
US04624961

Reaction notes

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