HCID 20226665, compound → HCID 20226652, compound

HRID 1732104Notes

Reaction equation

HRID 1732104 reaction equation
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:25]=[CH:26][CH:27]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[CH2:19][CH:18](O)[CH:17](O)[CH2:16][C:15]=2[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[H][H]>C(O)C.[Pt]>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:25]=[CH:26][CH:27]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=2[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 2

HCID 20226665HCID 20226665, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20226652HCID 20226652, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

The intermediate 5,8-dihydroquinoline derivative from Example 5 is dissolved in ethanol and hydrogenated over platinum catalyst. Hydrogen uptake is monitored and the reaction stopped when exactly one equivalent of hydrogen is absorbed. The catalyst is removed by filtration and the filtrate concentrated and chromatographed to give the title compound.

Workup

  1. customis absorbed
  2. customThe catalyst is removed by filtration
  3. concentrationthe filtrate concentrated
  4. customchromatographed

Sources & evidence

ORD record
ord-9c5383498e39488ba7bc33a573e6e1b6
Source dataset
uspto-grants-1986_11
Patent number
US04625034

Reaction notes

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