2-Aminothiazole → HCID 57076477, compound

HRID 1732305Notes

Reaction equation

HRID 1732305 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH2:7]([O:11][C:12]([C:14]#[C:15][C:16](OCCCC)=[O:17])=[O:13])[CH2:8][CH2:9][CH3:10]>C(O)C>[CH2:7]([O:11][C:12]([C:14]1[N:6]2[CH:5]=[CH:4][S:3][C:2]2=[N:1][C:16](=[O:17])[CH:15]=1)=[O:13])[CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 305768dibutyl but-2-ynedioate

Product 1

HCID 57076477HCID 57076477, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The procedure is as in Example 22, except that 5 g of 2-aminothiazole are reacted with 11.3 g of acetylene dicarboxylic acid di-n-butyl ester in presence of 50 ml of absolute ethanol. 7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid n-butyl ester melting at 142°-144° C. is thus obtained in a yield of 8.1 g (64.3% of the theoretical).

Sources & evidence

ORD record
ord-0b271b0090714c4e8837722f58cfedb8
Source dataset
uspto-grants-1980_12
Patent number
US04237136

Reaction notes

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