反应详情

p-Hydroxyacetophenone (13.6 g.), 1,3-dibromopropane (121.2 g.) and potassium carbonate (15.8 g.) were dissolved in acetone (250 ml.), and the solution was refluxed under heating for 6 hours. After the reaction mixture was filtered, the acetone was removed by evaporation from the filtrate under reduced pressure to give an oily residue. The excess of 1,3-dibromopropane was removed by distillation from the oily residue under reduced pressure to give a residue, which was subjected to column chromatography on silica gel (20 g.). Elution was carried out with benzene and the fractions containing a desired compound were collected. The eluate was evaporated to dryness under reduced pressure to give p-(3-bromopropoxy)acetophenone (18 g.).

1. temperaturethe solution was refluxed
2. temperatureunder heating for 6 hours
3. filtrationAfter the reaction mixture was filtered
4. customthe acetone was removed by evaporation from the filtrate under reduced pressure
5. customto give an oily residue
6. customThe excess of 1,3-dibromopropane was removed by distillation from the oily residue under reduced pressure
7. customto give a residue, which
8. washElution
9. additionthe fractions containing a desired compound
10. customwere collected
11. customThe eluate was evaporated to dryness under reduced pressure