反应详情

温度

100 °C

A mixture of 2,5-dichloro-4-nitroaniline (7.0 g), phenol (3.2 g), potassium carbonate (9.7 g) and dry dimethylformamide (50 ml) is stirred and heated at 100° C. for 7.5 hours. The mixture is then poured into 500 ml of ice water and stirred. The aqueous mixture is extracted with ethyl acetate (5×200 ml), the extracts are dried and evaporated to dryness. The residual oil is stirred with methylene chloride (20 ml), the resulting solid is collected and dried to yield 3.5 g of title product, m.p. 122°-124° C.

1. stirringstirred
2. extractionThe aqueous mixture is extracted with ethyl acetate (5×200 ml)
3. customthe extracts are dried
4. customevaporated to dryness
5. stirringThe residual oil is stirred with methylene chloride (20 ml)
6. customthe resulting solid is collected
7. customdried