Water → HCID 825289, compound

HRID 1732892Notes

Reaction equation

HRID 1732892 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11](Cl)=[O:12].O>C1(C)C=CC=CC=1>[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11]([N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:12]

Participants

5

Reactant 3

HCID 962WaterHCID 31268PyrrolidineHCID 789282-Thiophenecarbonyl chloride

Product 1

HCID 825289HCID 825289, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Pyrrolidine (47 ml) was added to 2-thiophene carbonyl chloride (40 g) in toluene below 10°. After 11/2 hr, water was added. The product was extracted with ethyl acetate, crystallised from toluene and recrystallised from light petroleum (b.p. 60°-80°)/ethyl acetate to give white crystals (40 g) m.p. 66°-68°; TLC silica/ethyl acetate Rf 0.5.

Workup

  1. extractionThe product was extracted with ethyl acetate
  2. customcrystallised from toluene
  3. customrecrystallised from light petroleum (b.p. 60°-80°)/ethyl acetate

Sources & evidence

ORD record
ord-31a5f175c9fe4340935617abafbacddc
Source dataset
uspto-grants-1980_12
Patent number
US04239769

Reaction notes

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