Dimethylformamide → HCID 13402054, compound

HRID 1732920Notes

Reaction equation

HRID 1732920 reaction equation
[OH:1][C:2]1[C:3]2[S:10][C:9]3[N:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[N:6][N:7]=1.[C:16]([O-])([O-])=O.[K+].[K+].CN(C=O)C.CI>O>[CH3:16][N:7]1[C:2](=[O:1])[C:3]2[S:10][C:9]3[N:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[N:6]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178422889HCID 178422889, compound

Product 1

HCID 13402054HCID 13402054, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 6 g. (0.028 M) of 4-hydroxy-7-methylpyrido[3',2':4,5]thieno[3,2-d]-1,2,3-triazine, 12 g. of K2CO3 in 150 ml. DMF at 75° C. was added 6 ml. methyl iodide and stirring at this temperature was continued for 3 hours. The mixture was then diluted with water and the precipitated product was collected by filtration. Crystallization with chloroform gave m.p. 169°-171° C.

Workup

  1. additionTo a mixture of 6 g
  2. filtrationthe precipitated product was collected by filtration
  3. customCrystallization with chloroform
  4. customgave m.p. 169°-171° C.

Sources & evidence

ORD record
ord-bc50a5511a4c466088ef8ae13a3c246f
Source dataset
uspto-grants-1980_12
Patent number
US04239887

Reaction notes

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