Hydrochloric Acid → 3-(4'-Fluoro-4-biphenylyl)butylamine, hydrochloride

HRID 1733064Notes

Reaction equation

HRID 1733064 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH3:9])C(=O)C2=CC=CC=C12.[ClH:29]>>[ClH:29].[F:22][C:19]1[CH:18]=[CH:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([CH:8]([CH3:9])[CH2:7][CH2:6][NH2:5])=[CH:11][CH:12]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 203019791-Phthalimido-3-(4'-fluoro-4-biphenylyl)butane

Product 1

HCID 203027163-(4'-Fluoro-4-biphenylyl)butylamine, hydrochloride

Procedure

37.3 g of 1-phthalimido-3-(4'-fluoro-4-biphenylyl)butane are boiled for 6 hours with 400 ml of 20% aqueous hydrochloric acid, evaporated and worked up using sodium hydroxide solution and ether to give 3-(4'-fluoro-4-biphenylyl)butylamine, hydrochloride, m.p. 222°-224°.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-2608ab0b49d742eb968b25e2e0900b6c
Source dataset
uspto-grants-1980_12
Patent number
US04239759

Reaction notes

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