Methylamine → HCID 20300367, compound

HRID 1733150Notes

Reaction equation

HRID 1733150 reaction equation
[C:1]([C:3]1[C:7]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:6][O:5][C:4]=1[N:12]=[C:13]=[O:14])#[N:2].[CH3:15][NH2:16]>C1(C)C=CC=CC=1>[C:1]([C:3]1[C:7]([C:8]([CH3:10])([CH3:11])[CH3:9])=[CH:6][O:5][C:4]=1[NH:12][C:13]([NH:16][CH3:15])=[O:14])#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20300373HCID 20300373, compound

Product 1

HCID 20300367HCID 20300367, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 7.8 g (0.041 mole) of 3-cyano-4-tert.-butyl-fur-2-yl isocyanate in 30 ml of toluene was added dropwise to a solution of 1.6 g (0.052 mole) of methylamine in 30 ml of toluene. Thereafter, the mixture was worked up by concentrating it under reduced pressure and recrystallizing the residue from toluene. 6.8 g of 1-(3-cyano-4-tert.-butyl-fur-2-yl)-3-methylurea of melting point 163° C. were obtained in this manner.

Workup

  1. concentrationby concentrating it under reduced pressure
  2. customrecrystallizing the residue from toluene

Sources & evidence

ORD record
ord-45f5bcc81ab54c0089791ebbd6be2937
Source dataset
uspto-grants-1980_12
Patent number
US04240820

Reaction notes

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