2-Chloroethyl isocyanate → HCID 54186845, compound

HRID 1733214Notes

Reaction equation

HRID 1733214 reaction equation
O=[CH:2][C@@H:3]([C@H:5]([C@H:7]([C@@H:9]([CH2:11][OH:12])[OH:10])[OH:8])[OH:6])[OH:4].[CH3:13][CH:14]([NH2:18])[CH2:15][O:16][CH3:17].[Cl:19][CH2:20][CH2:21][N:22]=[C:23]=[O:24]>>[Cl:19][CH2:20][CH2:21][NH:22][C:23]([N:18]([CH:14]([CH3:13])[CH2:15][O:16][CH3:17])[CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[OH:4])=[O:24]

Participants

4

Reactant 3

HCID 160352-Chloroethyl isocyanateHCID 123458MethoxyisopropylamineHCID 3037556(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal

Product 1

HCID 54186845HCID 54186845, compoundYield 53.3%

Procedure

3.6 g of D-galactose, 3.5 g of (1-methyl-2-methoxy-ethyl)amine and 3.5 g of 2-chloroethyl isocyanate are treated in the same manner as described in Example 13-(1). 3.8 g of 1-(2-chloroethyl)-3-(1-methyl-2-methoxy-ethyl)-3-(D-galactopyranosyl)urea are thereby obtained as colorless caramel.

Sources & evidence

ORD record
ord-70c95e44159245fe9284573b3dd2a58b
Source dataset
uspto-grants-1980_12
Patent number
US04241053

Reaction notes

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